The Gunners on the other hand will be missing two players, most likely – Mesut Ozil will remain on the side-lines due to the back spasms that have kept him out of the past two matches and Granit Xhaka will not compete as the midfielder has amassed five yellow cards already.United-Arsenal, to take away current situations a little, is arguably the biggest game in the Premier League, and always marks an occasion. Whether it’s moments of footballing history such as Patrick Viera vs. Roy Keane in the tunnel; the lowest-of-lows back in 2011 when Alex Ferguson’s team won the day 8-2; or one Thierry Henry sending Highbury into ecstasy back in 2000 with an astonishing acrobatic volley, this is a game that rarely disappoints.Fortunes have changed a little over the last few years for both sides, but there’s no doubt that this game still represents a massive opportunity for both sides to lay down a marker. For Arsenal, it’s a chance to claim a second scalp from the perceived “top 6” in a week; for United, it’s a chance for their manager to stake a claim for holding onto his job going into the second half of the season.For those keeping score, Manchester United are unbeaten in 11 home league matches against Arsenal since September 2006 (Winning 8, Drawing 3). Historically, they’re perhaps the team that Arsenal have had the most trouble with in the league, especially on-the-road.What may give Emery some hope despite this poor record is that United have conceded 23 goals in their opening 14 matches – it took them 30 games to reach that point last season. With this being the case, and Arsenal’s attacking players in good-form, there’s a fine opportunity to do some damage and put that unpleasant 12-year record to bed.To continue with numbers, here’s a very relevant figure – 16. If Emery can claim a win on Wednesday night, he will have equalled his side’s entire last campaign away-point haul of 16 after just 7 games – they’ve already equalled the away win record of 4 from Wenger’s last season.But, regardless of form, this is Manchester United – a team not to be taken lightly. Rarely has there seemed a time that suits better to play them on home turf, with injury numbers high and spirts low, but they could still surprise and pull out the kind of performance they have been lacking in recent months.To conclude: the 82 most recent league and cup encounters between these two sides had featured one or both of Sir Alex Ferguson and Arsene Wenger at the helm – this time it’s Mourinho vs. Emery, and both manager’s will be desperate to claim all 3 points.Arsenal travel to Old Trafford to come-up against Manchester United on Wednesday the 5th of December in the Premier League, with kick-off scheduled for 8PM.